2H-Indol-2-one, 3-[3-[(3,4-dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-
Indirubin Derivative E804
CAS: 854171-35-0
Molecular Formula: C20H19N3O4
2H-Indol-2-one, 3-[3-[(3,4-dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro- - Names and Identifiers
2H-Indol-2-one, 3-[3-[(3,4-dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro- - Physico-chemical Properties
| Molecular Formula | C20H19N3O4 |
| Molar Mass | 365.38 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Appearance | Solid |
| pKa | 10.81±0.20(Predicted) |
| Storage Condition | -20C |
| In vitro study | Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC 50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC 50 of 0.23 μM. |
2H-Indol-2-one, 3-[3-[(3,4-dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro- - Reference Information
| biological activity | Indirubin Derivative E804, which is a potent inhibitor of insulin-like growth factor type 1 receptor (IGF1R), the IC50 value was 0.65 μm. |
| Target | IC50: 0.65 μm (IGF1R). |
Last Update：2024-04-09 21:04:16
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